Diabetes Mellitus in the Cat

Feline Diabetes treatment

 

What is diabetes mellitus?

Diabetes is a condition caused by a deficiency in a very important hormone known as insulin. Insulin is made by the pancreas, and released into the bloodstream. It helps to control and regulate blood glucose levels. Insulin’s main job is to help move glucose from the bloodstream into the cells and tissues of the body. Once in the cell, glucose is used as an important energy source for needed cell functions. It is somewhat analogous to gasoline that is put into the car which allows the car to go.

What causes diabetes?

The cause of diabetes is different depending on the species (eg, cat versus dog). In the cat, diabetes is often associated with the deposition of amyloid (a type of protein) in the pancreas that is thought to interfere with subsequent insulin production. Other contributory causes in the cat include obesity and sometimes chronic pancreatitis. In dogs, diabetes usually occurs secondary to immune-mediated destruction (self-attack) of that part of the pancreas that makes insulin. The cause of this destruction is unknown although genetic predisposition and environmental factors may play a role in some.

What are common clinical signs?

Without insulin, even though there may be plenty of glucose in the bloodstream, it cannot move into the cell and the cells essentially starve in the face of plenty. The animal starts to show clinical signs due to glucose deficiency inside the cell as well as the excessive build up of glucose in the blood. Each patient is a bit different in the symptoms that they show, but some common clinical signs that may occur include hunger (as the brain senses a lack of glucose), weakness, increased urination (as excess glucose in blood is filtered by kidneys and lost in the urine along with water), and increased thirst (to compensate for increased water loss in the urine). Another common clinical problem that may occur includes bacterial infection in the bladder (glucose is a good energy source for bacteria). Additionally, in dogs, vision loss may occur due to the formation of cataracts (a white opacity of the normally clear lens of the eye). Due to different pathways of glucose movement within the eye that occur in the cat, cataract formation is not common in the diabetic cat.

How is diabetes diagnosed?

Diabetes is diagnosed based on history, clinical signs and the results of routine screening tests (CBC, biochemistry profile, urinalysis). Other tests (urine culture, blood pressure assessment, and others) may be recommended based on the results of the screening tests.
 

How is diabetes treated?

Insulin therapy makes up the cornerstone of management, although dietary management is a very important considerations as well. Initial hospitalization may be recommended after the diagnosis is made, so insulin therapy can be started in the hospital. Several (2 to 4 or more) spot blood glucose levels are checked within the 4 to 12 hours after insulin is given to make sure the starting insulin dose is not too high. Once discharged, your pet will need to continue to receive insulin shots on a daily basis at home. It will likely be a bit new and confusing at first, but our nurses will help teach you how to give the insulin injections and in a short time, the process should become quite familiar and comfortable. 
Increased thirst and appetite is common in diabetic animalsIncreased thirst and appetite is common in diabetic animals
Increased thirst and appetite is common in the diabetic
 

What type of home care is recommended for the cat with diabetes?

 
In general, home care involves the consistent administration of insulin as well as a specially formulated diet and feeding schedule. Some general guidelines in these areas include:
1. Diet: regular daily feedings given at the same time each day (for example, 7 am and 7 pm) help to maintain optimum diabetic regulation. Maintaining an appropriate body weight is also important (we will help you determine the optimum weight for your pet). Specific guidelines for exactly how much to feed, when to feed and what type of diet to feed will be recommended.
2. Recommended diets: in general, a high protein low carbohydrate diet is the preferred choice for the diabetic cat. In some patients, additional diseases or medical concerns may necessitate alternative dietary choices. There are a variety of excellent choices available today for the diabetic cat.
Insulin and Insulin SyringesInsulin and Insulin Syringes
Insulin & Insulin Syringes
 

How is insulin therapy given?

There are several different types of insulin to choose from for treatment of diabetes. Generally speaking, at the time of diagnosis, an appointment time will be set up so the nurse and doctor can go over specific recommendations as to the type of insulin recommended, dose recommended, and special precautions that need to be taken in regards to appropriate storage and handling of insulin for your pet. The doctor and nurse will also teach you how to give insulin shots, so you are very comfortable and confident before you leave the office and embark on home care on your own.
Sites to administer Insulin injectionsGiving an injection to a cat
Sites to Administer Insulin Injections        Giving an injection to a cat

What type of monitoring and rechecks are recommended?

Diabetes is often a constantly changing disease and frequent veterinary rechecks are often necessary to help guide therapy and provide for the early detection of complications. Some general guidelines include the following:
1. Regular rechecks: after preliminary regulation of diabetes has been achieved, your pet should return for a recheck evaluation (examination, CBC, profile, UA and urine culture) every 4 to 6 months.
 
2. Glucose profile
This test involves taking a very small sample of blood every 2 hours for 12 to 24 hours. It is critical in determining how your pet is responding to insulin therapy. Glucose profiles are done initially to determine the best insulin dose, as well as whenever the insulin dose is changed, or if clinical signs suggest poor regulation.
 
3. Planning for the recheck blood glucose profile
When you return for a blood glucose profile, the doctor will often ask you to bring with you in a small cooler your pet’s insulin, insulin syringes, and enough food for the next meal. We will likely ask you to feed your pet breakfast at home before you come. When you arrive at the clinic, a nurse will assist you while you administer your pet’s morning insulin shot. The nurse will then get your pet set up in a comfortable cage for the glucose profile, while you fill out a recent history form letting us know how your pet has been doing and if any new problems have arisen.
 
4. Other testing
If your cat becomes sick, or develops symptoms which suggest poor regulation (decreased appetite, increased thirst, increased urination, urinary accidents in the house, depression, etc), then a recheck visit should be scheduled more immediately.
 
5. What about glucose monitoring of the urine?
As excess glucose can be noted in the urine both with insulin overdose and underdose, this method is not recommended for monitoring.
 

What about home blood glucose monitoring?

If you are interested in performing home glucose profiles, our nurses can assist in teaching you to perform this testing (many owners do this very successfully at home). You will need to be taught how to obtain blood samples from your cat (our nurse can show you during an appointment time) and you will need to purchase a device that measures glucose levels in the blood (a glucometer). Our currently recommended glucometer is AlphaTrak by Abbott Veterinary. During the beginning stages of insulin therapy, it is important to bring along your glucometer with your pet during scheduled blood glucose rechecks (so we can compare the values with our in house glucose lab measurements to insure accuracy). Once we are certain that blood glucose values agree with those obtained in our clinic, blood glucose profiles can be performed at home and the results reported to the doctor for ongoing recommendations in regards to insulin therapy.
 
Wendy Yaphe, DVM, DACVIM & Corinne Fabrick, DVM, DACVIM-Aspen Meadow Veterinary Specialists
 
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